Description
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].—Neuroscience-Neuromodulation–C176H269N51O48S6.xC2HF3O2——–N/A—-OC(C(F)(F)F)=O.O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CC5=CNC=N5)=O)NC1=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N7[C@@H](CCC7)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CC=CC=C8)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN–Neurological Disease–H2O–Sodium Channel—-Membrane Transporter/Ion Channel–Peptides
