Description

PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].—COVID-19-immunoregulation–C51H69N13O9—-[1]Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides–944111-22-2–1008.18—-[Ac-{Nle}-D-{Bal}-{D-Nal}-RWK-NH2 (Lactam bridge:Asp2-Lys7)]–Inflammation/Immunology–10 mM in DMSO–Melanocortin Receptor–MC3R–GPCR/G Protein;Neuronal Signaling–Peptides