Description

PEN (rat) TFA, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].—–C102H169N27O33.xC2HF3O2—-[1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.—-2301.59 (free base)—-O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N1[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)C)=O)=O)CC(C)C)=O)C(C)C)=O)CC(N)=O)=O)CCC(O)=O)=O)CCC3)=O)CCC2)=O)C(C)C)=O)CCC(O)=O)=O)CCC1)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)C(C)C.OC(C(F)(F)F)=O.[x]–Neurological Disease–10 mM in DMSO–G protein-coupled Bile Acid Receptor 1—-GPCR/G Protein–Peptides