Description

PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].—–C102H169N27O33—-[1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.–569364-13-2–2301.59—-O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H]3N(CCC3)C(CNC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@@H](N)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O–Neurological Disease–10 mM in DMSO–G protein-coupled Bile Acid Receptor 1—-GPCR/G Protein–Peptides