OSK-1-Get quote
Description
OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent[1].—COVID-19-immunoregulation–C177H300N56O46S8—-[1]Stéphanie Mouhat, et al. K<sup>+</sup> channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104.–183815-75-0–4205.17—-O=C1NC(CCCCCC(C2OC2)O)C(NC(C)(C)C(NC(CC3=CC=CC=C3)C(N4CCCC14)=O)=O)=O–Inflammation/Immunology; Neurological Disease–H2O–Potassium Channel—-Membrane Transporter/Ion Channel–Peptides