Description

Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].—Metabolism-sugar/lipid metabolism–C49H66N10O10S2.xC23H16O6—-[1]G. Weckbecker，et al. Indirect antiproliferative effect of the somatostatin analog octreotide on MIA PaCa-2 human pancreatic carcinoma in nude mice. Yale J Biol Med. 1997 Sep-Dec;70(5-6):549-54.|[2] Chand Khanna，et al. A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy. Clin Cancer Res. 2002 Jul;8(7):2406-12|[3]Xiao-Xia Wang,et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16(1):109-118.–135467-16-2–N/A—-OC(C1=CC(C=CC=C2)=C2C(CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4)=C1O)=O.O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC5=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](N)CC6=CC=CC=C6)=O)=O)CC7=CC=CC=C7)N[C@@H]5CC8=CNC9=CC=CC=C89.[x]–Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease–10 mM in DMSO–Apoptosis;Somatostatin Receptor–SSTR2;SSTR3;SSTR5–Apoptosis;GPCR/G Protein;Neuronal Signaling–Peptides