Description

Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neuromodulation–C63H91N15O11S—-[1][2] Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997). |[2]Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335. |[3]Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54.—-1266.56–98.70–O=C([C@@H](N)CCSC)N1[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CCC2)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC4=CNC5=CC=CC=C45)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)CCC1.CC(O)=O–Cancer; Endocrinology; Metabolic Disease–H2O : 50 mg/mL (ultrasonic)–Melanocortin Receptor–MC1R;MC3R;MC4R;MC5R–GPCR/G Protein;Neuronal Signaling–Peptides