Nociceptin (1-13), amide (TFA)-5 mg

Description

Nociceptin (1-13), amide TFA is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neuromodulation–C63H101F3N22O17—-[1]Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.|[2]Calo’ G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.—-1495.61–99.67–O=C(C(F)(F)F)O.C[C@H]([C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)=O)NC([C@@H](NC(CNC(CNC([C@H](CC1=CC=CC=C1)N)=O)=O)=O)CC2=CC=CC=C2)=O)O–Neurological Disease–DMSO : ≥ 100 mg/mL–Opioid Receptor–NOP Receptor/ORL1–GPCR/G Protein;Neuronal Signaling–Peptides