Description

NMS-P945 is an ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs). NMS-P945 is suitable for conjugation to mAbs with reproducible Drug Antibody Ratio (DAR) >3.5[1].–Applications–Formula-C61H76ClN11O12S-Citation–References-[1]Valsasina B, Novel thienoduocarmycin-trastuzumab ADC demonstrates Strong Anti-tumor Efficacy with Favorable Safety Profile in Preclinical Studies. Mol Cancer Ther. 2023 Sep 19. -CASNumber-1466546-35-9-MolecularWeight-1222.84-Compound Purity–SMILES-O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(N(C)CCN(C)C(OC(C3=C4C(C)=CS3)=CC5=C4[C@H](CCl)CN5C(C6=CC(C=C(C=C7)OCCN8CCCC8)=C7N6)=O)=O)=O)C=C2)=O)=O)=O)C=CC1=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related