Description

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)—-C162H276F3N55O31—-[1]Dietrich L, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions. Cell Chem Biol. 2017 Aug 17;24(8):958-968.e5.|[2]Wang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41(4):2109-2129.—-3559.28–99.14–OC(C[C@H](NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)N1)=O)=O)C(N[C@@](C(NC)=O)(C)CCC/C=CCCC[C@](C)(NC)C1=O)=O)=O.[VH]N[C@H](C(N[C@H](C([V][W]N[C@H](C(N)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N.OC(C(F)(F)F)=O.[PKKKRKV-PEG2-Har-Har-WP-Har]–Cancer–DMSO : 100 mg/mL (ultrasonic)–Wnt;β-catenin—-Stem Cell/Wnt–Peptides