Description

NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].–20°C (Powder, protect from light)-Applications-Cancer-programmed cell death-Formula-C30H30F4N4O7-Citation–References-[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.-CASNumber-1817857-35-4-MolecularWeight-634.58-Compound Purity-99.80-SMILES-OC(C(F)(F)F)=O.NC[C@H](C)C(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;Topoisomerase-Isoform-Camptothecins-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related