Description

mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1].—–C93H150N20O25—-[1]Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278(22):19634-41.–593267-11-9–1948.31—-OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O–others–10 mM in DMSO–ERK—-MAPK/ERK Pathway;Stem Cell/Wnt–Peptides