Description

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].–20°C (Powder, protect from light, stored under nitrogen)-Applications-Cancer-programmed cell death-Formula-C51H58N8O13-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber-1801838-28-7-MolecularWeight-991.05-Compound Purity-98.02-SMILES-O=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[C@]1(CC)OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O-Research_Area-Cancer-Solubility-DMSO : 28.57 mg/mL (ultrasonic)-Target-Drug-Linker Conjugates for ADC-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related