Description

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.–Applications-Cancer-programmed cell death-Formula-C21H34N6O6-Citation–References-[1]Zhang D, et al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274.-CASNumber-2639874-49-8 -MolecularWeight-466.53-Compound Purity–SMILES-O=C(O)[C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC(CCCCCN(C1=O)C(C=C1)=O)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related