Description

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3].—Neuroscience-Neuromodulation–C39H64N8O10—-[1]Rupniak NMJ, et al. Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4-10) on bladder and colorectal activity in minipigs. Neuropeptides. 2019 Oct;77:101956. |[2]Rupniak NMJ, et al. [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs. J Pharmacol Exp Ther. 2018 Jul;366(1):136-144. |[3]Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019. –149270-28-0–804.97—-OC(C[C@H](N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N(C)[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCC)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor–NK2–GPCR/G Protein;Neuronal Signaling–Peptides