Description

Lys-Nε-SPDB-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody agent conjugate (ADC)[1].–Applications-Cancer-programmed cell death-Formula-C48H72ClN5O13S2-Citation–References-[1]Hans K Erickson, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006 Apr 15;66(8):4426-33.-CASNumber-1280215-91-9-MolecularWeight-1026.69-Compound Purity–SMILES-C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(NCCCC[C@H](N)C(O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)C)OC)(NC(O3)=O)O)C)([H])O1-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Drug-Linker Conjugates for ADC-Isoform-Maytansinoids-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related