Description

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells[1][2][3]. This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome[4].–20°C, 3 years; 4°C, 2 years (Powder)-Applications-COVID-19-immunoregulation-Formula-N/A-Citation–References-[1]Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404.|[2]Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32.|[3]Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337.|[4]Gayle DA, et al. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res. 2002 Jan 31;133(1):27-35.|[5]Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433. -CASNumber–MolecularWeight-N/A-Compound Purity–SMILES-[Lipopolysaccharides]-Research_Area-Inflammation/Immunology-Solubility- H2O : 5 mg/mL (ultrasonic)|DMSO : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)-Target-Toll-like Receptor (TLR)-Isoform-TLR4-Pathway-Immunology/Inflammation-MCE Product type-Biochemical Assay Reagents