Description

Linopristin is a kind of type B streptogramin antibiotics. Linopristin, together with type A, Flopristin, to form the streptogramin combination NXL 103. Linopristin exhibit synergistic antimicrobial activity against certain pathogenic bacteria with Flopristin. The preference ratio of Linopristin/Flopristin is 30:70 (w/w) or 70 μM Linopristin +120 μM Flopristin[1].—–C50H63N9O10—-[1]Noeske J, et al. Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob Agents Chemother. 2014 Sep;58(9):5269-79. –325965-23-9–950.09—-O=C1N2[C@](CC=C(C2)CN3CCOCC3)([H])C(N[C@@H](C4=CC=CC=C4)C(O[C@@H]([C@@H](C(N[C@@H](C(N5[C@](CCC5)([H])C(N([C@H]1CC6=CC=C(C=C6)N(C)C)C)=O)=O)CC)=O)NC(C7=C(C=CC=N7)O)=O)C)=O)=O–Infection–10 mM in DMSO–Antibiotic;Bacterial—-Anti-infection–Peptides