L803-mts-Get quote

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L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test[1][2].—–C66H110N15O20P—-[1]Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55(8):781-4.|[2]Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288(2):1295-306.–1043881-55-5–1464.64—-O=C([C@H](CCC1)N1C([C@H](C)NC([C@H](CCC2)N2C([C@H](CCC3)N3C([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC(CNC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCC(N)=O)C(N[C@@H](CO[P](O)(O)=O)C(N(CCC5)[C@@H]5C(N)=O)=O)=O)=O–Neurological Disease–10 mM in DMSO–Amyloid-β;GSK-3—-Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt–Peptides

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MEDCHEM EXPRESS