Description

L-Palmitoylcarnitine-d3 (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].-4°C (Powder, sealed storage, away from moisture)-Applications–Formula-C23H43D3ClNO4-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.-CASNumber-1334532-26-1-MolecularWeight-439.09-Compound Purity-99.83-SMILES-CCCCCCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C([2H])([2H])[2H])=O.[Cl-]-Research_Area-Metabolic Disease; Cardiovascular Disease-Solubility-10 mM in DMSO-Target-Endogenous Metabolite;Potassium Channel-Isoform–Pathway-Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease-MCE Product type-Isotope-Labeled Compounds