Description
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively[1].–Applications–Formula-C26H28D3Cl2N7O3-Citation–References-[1]Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T-CASNumber–MolecularWeight-563.49-Compound Purity–SMILES-CCN1CCN(C2=CC=C(NC3=NC=NC(N(C([2H])([2H])[2H])C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)=C3)C=C2)CC1-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-FGFR-Isoform–Pathway-Protein Tyrosine Kinase/RTK-MCE Product type-Isotope-Labeled Compounds
