Description

Hynic-PEG3-N3 is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Hynic-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.–Applications-Cancer-programmed cell death-Formula-C17H27N7O4-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber–MolecularWeight-393.44-Compound Purity–SMILES-C/C(C)=N/NC(N=C1)=CC=C1C(NCCOCCOCCOCCN=[N+]=[N-])=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Acid Cleavable Linker;Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related