Description

HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].—Metabolism-protein/nucleotide metabolism–C58H79N19O10S2—-[1]Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.–212370-59-7–1266.50—-[Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)]–Metabolic Disease–10 mM in DMSO–Melanocortin Receptor–MC4R–GPCR/G Protein;Neuronal Signaling–Peptides