Description

HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].—–C26H39N3O7—-[1]Anna Baldisserotto, et al. C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors. Eur J Med Chem. 2008 Jul;43(7):1403-11.–862891-04-1–505.60—-O=C(C(C=CC=C1O)=C1C)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)/C=C/C(OCC)=O)=O)=O–Others–10 mM in DMSO–Ser/Thr Protease—-Metabolic Enzyme/Protease–Peptides