Description

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].—Neuroscience-Neuromodulation–C47H65N9O9—-[1]Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96.|[2]Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5.–141663-86-7–900.07—-O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(OC(C)(C)C)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor–NK2–GPCR/G Protein;Neuronal Signaling–Peptides