Description

GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1].—Neuroscience-Neuromodulation–C50H72N12O9—-[1]A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.–141636-44-4–985.18—-O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](CCCNC(N)=N)NC(OC(C)(C)C)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides