Description

G0775 is a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 is active against MDR bacteria. G0775 binds the LepB protease domain[1].—Neuroscience-Neuromodulation–C47H59N11O7—-[1]Peter A Smith, et al. Optimized arylomycins are a new class of Gram-negative antibiotics. Nature. 2018 Sep;561(7722):189-194.–2098663-92-2–890.04—-CC(C)(C)C1=CC=C(C2=NC(C)=C(C(N[C@H](C(N([C@H](C3=O)C4=CC(C5=CC(C[C@@H](C(NCC#N)=O)NC([C@H](C)N3)=O)=CC=C5OCCN)=C(OCCN)C=C4)C)=O)CCN)=O)C=N2)C=C1–Infection; Inflammation/Immunology; Neurological Disease–10 mM in DMSO–Bacterial—-Anti-infection–Peptides