Description

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neurodegeneration–C33H43N7O9—-[1]Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.|[2]Chen G, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies. Sci Adv. 2021 Apr 16;7(16):eabe4499. –220701-06-4–681.74–99.62–NCCCC[C@@H](C(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O)=O)=O–Neurological Disease–DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : ≥ 10 mg/mL–Amyloid-β—-Neuronal Signaling–Peptides