Fmoc-8-amino-3,6-dioxaoctanoic acid-500 mg

Description

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].–20°C, 3 years; 4°C, 2 years (Powder)-Applications-Cancer-programmed cell death-Formula-C21H23NO6-Citation–References-[1]Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.-CASNumber-166108-71-0-MolecularWeight-385.41-Compound Purity-99.98-SMILES-O=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O-Research_Area-Cancer-Solubility-DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)-Target-ADC Linker;PROTAC Linkers-Isoform-Alkyl/ether Linkers;Cleavable Linker;PEG Linkers-Pathway-Antibody-drug Conjugate/ADC Related;PROTAC-MCE Product type-ADC Related