Description

Estrone sulfate-d5 (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].–Applications–Formula-C18H16D5NaO5S-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. |[3]Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303.|[4]Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21. -CASNumber-2734919-86-7-MolecularWeight-377.44-Compound Purity–SMILES-C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([2H])C4=CC=C(OS(=O)(O[Na])=O)C=C4C([2H])([2H])C3([2H])[2H]-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Endogenous Metabolite;Estrogen Receptor/ERR;Isotope-Labeled Compounds-Isoform–Pathway-Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor-MCE Product type-Isotope-Labeled Compounds