Description

Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].–Applications–Formula-C23H21D3N2O4S-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.-CASNumber-1185243-70-2-MolecularWeight-427.53-Compound Purity–SMILES-OC(/C(CC1=CC=CS1)=C/C2=CN=C(CCCC([2H])([2H])[2H])N2CC3=CC=C(C=C3)C(O)=O)=O-Research_Area-Cardiovascular Disease-Solubility-10 mM in DMSO-Target-Angiotensin Receptor;Isotope-Labeled Compounds-Isoform–Pathway-GPCR/G Protein;Others-MCE Product type-Isotope-Labeled Compounds