Description

Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neuromodulation–C77H120F3N25O19S2—Free Radic Biol Med. 2022 Feb 2;S0891-5849(22)00031-4.|Cell Stress Chaperones. 2022 Dec 13.|J Cardiovasc Transl Res. 2022 Feb 16;1-13.-[1]Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72.—-1821.05–98.78–OC(C(F)(F)F)=O.O=C(O)[C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H]3N(C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC4=CNC=N4)NC([C@H](CC(C)C)NC([C@H]5N(C([C@H](CCSC)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC6)NC6=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)CCC3)=O)=O)CCC1–Cardiovascular Disease–DMSO : 100 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)–Apelin Receptor (APJ);Arrestin—-GPCR/G Protein–Peptides