Description

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neuromodulation–C75H119N25O17S2—Cell Stress Chaperones. 2022 Dec 13.|J Cardiovasc Transl Res. 2022 Feb 16;1-13.|Free Radic Biol Med. 2022 Feb 2;S0891-5849(22)00031-4.-[1]Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72.–1886973-05-2–1707.03–98.05–O=C([C@@H]1CCC(N1)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O–Cardiovascular Disease–H2O : 100 mg/mL (ultrasonic)–Apelin Receptor (APJ);Arrestin—-GPCR/G Protein–Peptides