Description

ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)—-C58H90N16O13S2—-[1]Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.–1784687-32-6–1283.56–99.03–O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@@H](N)CS)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O–Inflammation/Immunology–H2O : 100 mg/mL (ultrasonic)–Apelin Receptor (APJ);Arrestin—-GPCR/G Protein–Peptides