Description

E104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs[1].–Applications–Formula-C21H23N5-Citation–References-[1]DeYoung EG, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368.-CASNumber-1610431-21-4-MolecularWeight-345.44-Compound Purity–SMILES-NC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CC4=CC=C(C=C4)N-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;Toll-like Receptor (TLR)-Isoform-TLR7-Pathway-Antibody-drug Conjugate/ADC Related;Immunology/Inflammation-MCE Product type-ADC Related