Description

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].–80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)–Neuroscience-Neuromodulation–C46H72N14O10—-[1]Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627.|[2]Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871.–75790-53-3–981.15–99.88–O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N–Neurological Disease–10 mM in DMSO–Endogenous Metabolite;Opioid Receptor–Human Endogenous Metabolite;κ Opioid Receptor/KOR–GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling–Peptides