Description

Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.–Applications-Cancer-programmed cell death-Formula-C26H25ClN4O3-Citation–References-[1]Searcey M. Duocarmycins–natures prodrugs? Curr Pharm Des. 2002;8(15):1375-89.-CASNumber-1613286-59-1-MolecularWeight-476.95-Compound Purity–SMILES-O=C(NC1=CC2=C(C=C1)C=C(C(N3C[C@@H](CCl)C4=C3C=C(O)C5=CC=CC=C45)=O)N2)CN(C)C-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;DNA Alkylator/Crosslinker-Isoform-Duocarmycins-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related