Description

DMEA-PNU-159682 (molecule D12) is a ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682[1][2].–Applications-Cancer-programmed cell death-Formula-C37H45N3O14-Citation–References-[1]Chen Jingkang, et al. Disubstituted maleic amide class connexon for antibody-drug conjugate and its preparation method and application. CN108101825A.|[2]John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1-CASNumber-1799421-48-9-MolecularWeight-755.76-Compound Purity–SMILES-C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCNC)=O)=O)(O)C4)C(O)=C6C(C(C7=C(OC)C=CC=C7C6=O)=O)=C5O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin-Isoform-Daunorubicins/Doxorubicins-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related