Description

DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs)[1].–20°C, 3 years (Powder)-Applications-Cancer-programmed cell death-Formula-C37H52ClN3O10S-Citation–References-[1]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).-CASNumber-796073-54-6-MolecularWeight-766.34-Compound Purity-95.59-SMILES-C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1-Research_Area-Cancer-Solubility-DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)-Target-ADC Cytotoxin;Microtubule/Tubulin-Isoform-Maytansinoids-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton-MCE Product type-ADC Related