Description

D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].—Neuroscience-Neuromodulation–C47H67N11O11S2—-[1]Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46.|[2]Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.–42061-33-6–1026.23—-[{Mpa}-YFLNCPKG-NH2 (Disulfide bridge:Mpa1-Cys6)]–Neurological Disease; Cardiovascular Disease–H2O–Vasopressin Receptor–V1b Receptor –GPCR/G Protein–Peptides