Description

Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity[1][2][3][4][5][6].-4°C (Powder, sealed storage, away from moisture and light)-Applications–Formula-C34H24N6Na4O16S4-Citation–References-[1]Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.|[2]Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.|[3]Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.|[4]Min JO, et al. Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Mol Brain. 2022 Mar 28;15(1):27.|[5]Jin K, et al. Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. Biochem Pharmacol. 2021 Oct;192:114734.|[6]He Z, et al. Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. Behav Brain Res. 2013 Feb 15;239:172-6.-CASNumber-2610-05-1-MolecularWeight-992.80-Compound Purity-95.0-SMILES-COC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(OC)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5-Research_Area-Inflammation/Immunology-Solubility-DMSO : 125 mg/mL (ultrasonic)|H2O : 2.08 mg/mL (ultrasonic)-Target-Amyloid-β;NF-κB-Isoform–Pathway-Neuronal Signaling;NF-κB-MCE Product type-Dye Reagents