Description

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM[1].–Applications-Cancer-programmed cell death-Formula-C39H54N10O12S-Citation–References-[1]Matinkhoo K, et, al. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292.-CASNumber-58255-46-2-MolecularWeight-886.97-Compound Purity–SMILES-C[C@H]([C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CC3=C(SC[C@H](N4)C(N2)=O)NC5=C3C=CC=C5)C(NCC(N[C@H](C(NCC4=O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](O)CO-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;DNA/RNA Synthesis-Isoform–Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related