Description

DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer[1].–Applications-Cancer-programmed cell death-Formula-C35H31ClN5O7PS2-Citation–References-[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.-CASNumber-615538-47-1-MolecularWeight-764.21-Compound Purity–SMILES-O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(OP(O)(O)=O)C7=CC=CC=C67)=O)=C4)C=C3-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin-Isoform-Duocarmycins-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related