Description

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].–20°C (Powder, stored under nitrogen)-Applications-Neuroscience-Neuromodulation-Formula-C31H24ClN5O3-Citation–References-[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.-CASNumber-615538-51-7-MolecularWeight-550.01-Compound Purity-95.00-SMILES-O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3-Research_Area-Cancer-Solubility-DMSO : 50 mg/mL (ultrasonic)-Target-ADC Cytotoxin-Isoform-Duocarmycins-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related