Description

DBCO-Val-Cit-PABC-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Val-Cit-PABC-OH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.–Applications-Cancer-programmed cell death-Formula-C39H46N6O6-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber–MolecularWeight-694.82-Compound Purity–SMILES-O=C(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)CCCCC(N[C@H](C(N[C@H](C(NC4=CC=C(C=C4)CO)=O)CCCNC(N)=O)=O)C(C)C)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Cleavable Linker;Protease Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related