Description

DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.–20°C (Powder, sealed storage, away from moisture)-Applications-Cancer-programmed cell death-Formula-C48H50N4O8-Citation–References-[1]Adam TIBBLES, et al. Engineered O-glycosylation in recombinant polypeptides via heterologous glycosylation sites. WO2019122234A1.-CASNumber-2182601-68-7-MolecularWeight-810.93-Compound Purity-97.39-SMILES-O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O-Research_Area-Cancer-Solubility-DMSO : 100 mg/mL (ultrasonic)-Target-ADC Linker;PROTAC Linkers-Isoform-Cleavable Linker;PEG Linkers-Pathway-Antibody-drug Conjugate/ADC Related;PROTAC-MCE Product type-ADC Related