Description

[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].—COVID-19-immunoregulation–C74H106N20O13S—-[1]Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31.|[2]Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. |[3]Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English.–80434-86-2–1515.82—-CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H]6N(C([C@H](CCCCN)NC([C@@H]7N(C([C@H](CCCNC(N)=N)N)=O)CCC7)=O)=O)CCC6)=O)=O)=O)=O)=O)=O)=O–Inflammation/Immunology–H2O–Neurokinin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides