Description

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].—Neuroscience-Neuromodulation–C67H87N15O14—-[1]H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. |[2]C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6.–109212-72-8–1326.50—-O=C([C@@H]1N(CCC1)C([C@@H](N)CC(O)=O)=O)N[C@@H](CC2=CN=CN2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides