Description

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)—-C164H286N66O40—-[1]Wang C, et al. Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling. Oncotarget. 2017 Oct 6;8(54):92864-92879.|[2]Wang J, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci. 2003 Sep 17;23(24):8596-607.|[3]Zhao Y, et al. The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Mol Cell Neurosci. 2012 Mar;49(3):300-10.|[4]Kersting S, et al. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium. J Inflamm Res. 2013 May 3;6:71-81.–1445179-97-4–3822.44–98.47–O=C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H](CCCNC(N)=N)C(N1[C@H](CCC1)C(N[C@H](C(C)C)C(N[C@H](CCC(N)=O)C(N2[C@H](CCC2)C(N[C@H](CC3=CC=CC=C3)C(N[C@H](CC(C)C)C(N[C@H](CC(N)=O)C(N[C@H](CC(C)C)C(N[C@H]([C@@H](O)C)C(N[C@H]([C@@H](O)C)C(N4[C@H](CCC4)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N5[C@@H](C(N[C@H](CCCNC(N)=N)C(N6[C@H](CCC6)C(N7[C@H](CCC7)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC(O)=O)N–Others–DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL–JNK–JNK–MAPK/ERK Pathway–Peptides