Description

Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1].–20°C (Powder, protect from light)-Applications-Cancer-programmed cell death-Formula-C52H83N7O13S-Citation–References-[1]Leal M, et al. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32. -CASNumber-1160590-05-5-MolecularWeight-1046.32-Compound Purity-99.91-SMILES-OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN3C(C(CC3=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)OC)=O)=O-Research_Area-Cancer-Solubility-DMSO : 200 mg/mL (ultrasonic)-Target-Microtubule/Tubulin-Isoform–Pathway-Cell Cycle/DNA Damage;Cytoskeleton-MCE Product type-ADC Related